rs199476315
A SNP in the TPM1 gene on chromosome 15. Its most notable genotype is A;G: Familial hypertrophic cardiomyopathy (possible)
- Gene
- TPM1
- Location
- Chr 1563,061,723 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;GMost notableBadFamilial hypertrophic cardiomyopathy (possible)
- G;GGoodcommon in clinvar
On SNPedia: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other TPM1 SNPs
- rs199476317A;GFamilial Hypertrophic CardiomyopathyVery important
- rs397516486C;GFamilial Hypertrophic CardiomyopathyVery important
- rs727503518A;GFamilial Hypertrophic CardiomyopathyVery important
- rs727504264C;GFamilial Hypertrophic CardiomyopathyVery important
- rs727504290C;GFamilial Hypertrophic CardiomyopathyVery important
- rs754664923A;GFamilial Hypertrophic CardiomyopathyVery important
- rs104894503A;GFamilial hypertrophic cardiomyopathy (possible)Very important
- rs28934269A;GFamilial Hypertrophic CardiomyopathyImportant
Notes
From SNPedia
Notes
The rare minor allele of this variant is reported to be pathogenic/likely pathogenic for familial hypertrophic cardiomyopathy (HCM), according to .
A;G
see discussion at rs199476315
Source and license
Adapted from rs199476315 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.