rs397516486
A SNP in the TPM1 gene on chromosome 15. Its most notable genotype is C;G: Familial Hypertrophic Cardiomyopathy
- Gene
- TPM1
- Location
- Chr 1563,061,758 (GRCh38)
- Highest magnitude
- 6.2Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CGoodcommon in clinvar
- C;GMost notableBadFamilial Hypertrophic Cardiomyopathy
On SNPedia: (C;C), (C;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other TPM1 SNPs
- rs199476317A;GFamilial Hypertrophic CardiomyopathyVery important
- rs727503518A;GFamilial Hypertrophic CardiomyopathyVery important
- rs727504264C;GFamilial Hypertrophic CardiomyopathyVery important
- rs727504290C;GFamilial Hypertrophic CardiomyopathyVery important
- rs754664923A;GFamilial Hypertrophic CardiomyopathyVery important
- rs104894503A;GFamilial hypertrophic cardiomyopathy (possible)Very important
- rs199476315A;GFamilial hypertrophic cardiomyopathy (possible)Very important
- rs28934269A;GFamilial Hypertrophic CardiomyopathyImportant
Source and license
Adapted from rs397516486 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.