rs2118181

A SNP in the FBN1 gene on chromosome 15. Its most notable genotype is C;C: X1.8 higher risk of Thoracic aortic dissection.

Gene
FBN1
Location
Chr 1548,623,687 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedX1.8 higher risk of Thoracic aortic dissection.Typical · 0.014% of people
  2. C;TNot ratedX1.32 higher risk of thoracic aortic dissectionTypical · 0.040% of people
  3. T;TNot ratedNormalTypical · 0.046% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageC;C 14% C;T 40% T;T 46%
  • European ancestry (Utah)C;C 2% C;T 17% T;T 81%
  • Han Chinese (Beijing)C;C 10% C;T 36% T;T 54%
  • Japanese (Tokyo)C;C 17% C;T 48% T;T 35%
  • Yoruba (Nigeria)C;C 25% C;T 60% T;T 15%
  • African ancestry (Southwest US)C;C 30% C;T 42% T;T 28%
  • Chinese (Denver)C;C 6% C;T 37% T;T 58%
  • Gujarati IndianC;C 2% C;T 30% T;T 68%
  • Luhya (Kenya)C;C 32% C;T 49% T;T 19%
  • Maasai (Kenya)C;C 14% C;T 56% T;T 30%
  • TuscanC;C 2% C;T 29% T;T 69%

Other FBN1 SNPs

All FBN1 SNPs

Notes

From SNPedia

Notes

Genetic variants in FBN-1 and risk for thoracic aortic aneurysm and dissection. Genome-wide association study identifies a susceptibility locus for thoracic aortic aneurysms and aortic dissections spanning FBN1 at 15q21.1.

Source and license

Adapted from rs2118181 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.