rs2145418

A SNP on chromosome 1. Its most notable genotype is C;C: 9.2x increased thyroid cancer risk

Gene
None listed
Location
Chr 1118,422,631 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe
Minor allele frequency
26%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;CMost notableBad9.2x increased thyroid cancer riskWorth knowing · 2.57% of people
  2. A;CBad5.0x increased thyroid cancer riskWorth knowing · 2.238% of people
  3. A;AGoodnormalTypical · 0.055% of people

SNPedia records rs2145418 on the minus strand: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 7% A;C 38% A;A 55%
  • European ancestry (Utah)C;C 4% A;C 31% A;A 65%
  • Han Chinese (Beijing)C;C 6% A;C 39% A;A 55%
  • Japanese (Tokyo)C;C 3% A;C 38% A;A 59%
  • Yoruba (Nigeria)C;C 13% A;C 39% A;A 48%
  • African ancestry (Southwest US)C;C 7% A;C 46% A;A 47%
  • Chinese (Denver)C;C 6% A;C 50% A;A 44%
  • Gujarati IndianC;C 1% A;C 33% A;A 66%
  • Luhya (Kenya)C;C 4% A;C 43% A;A 54%
  • Mexican ancestry (Los Angeles)C;C 21% A;C 37% A;A 42%
  • Maasai (Kenya)C;C 8% A;C 39% A;A 53%
  • TuscanC;C 5% A;C 28% A;A 67%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 120 words

rs2145418 is a SNP in the chromosome 1p12-13 region. In a case-control association study in a Spanish population, rs2145418 was associated with increased risk for thyroid cancer. rs2145418(G;T) heterozygotes had an odds ratio of 5.0 (CI: 2.85 - 8.83), while (G;G) homozygotes had an increased odds ratio of 9.2 (CI: 4.50 - 21.6), with reported significance of p < 0.0001.

C;C

but only reported in a single study, with no replication in 9 years. Population frequency for the genotype is also ~5%, far too high to be as negative as this sounds.

A;C

but only reported in a single study, with no replication in 9 years. Population frequency for the genotype is also ~30%, far too high to be as negative as this sounds.

Source and license

Adapted from rs2145418 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.