rs2230199
A SNP in the C3 gene on chromosome 19. Its most notable genotype is C;G: 1.6x+ risk of ARMD
- Gene
- C3
- Location
- Chr 196,718,376 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 10%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs2230199 on the minus strand: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageG;G 91% C;G 8% C;C 1%
- European ancestry (Utah)G;G 66% C;G 29% C;C 5%
- Han Chinese (Beijing)G;G 100% C;G 0% C;C 0%
- Japanese (Tokyo)G;G 100% C;G 0% C;C 0%
- Yoruba (Nigeria)G;G 97% C;G 3% C;C 0%
Related
Notes
From SNPedia
Notes
rs2230199, a SNP in the complement component C3 gene, has been reported by several investigators to be associated with ARMD. The common allele at this SNP is known as Arg102; the variant and risk allele is known as Gly102. The risk allele, in orientation to the dbSNP entry for this rs#, is (G). In one of the largest case-control studies, the odds ratio associated with heterozygotes is 1.61, and for homozygotes, 3.26 (p = 4.5 x 10e-12). NEJM reports significant associate with ARMD. blog post
Source and license
Adapted from rs2230199 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.