rs2230201

A SNP in the C3 gene on chromosome 19. Its most notable genotype is C;C: >1.4x risk of lupus

Gene
C3
Location
Chr 196,713,280 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
22%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TNot ratednormal riskTypical · 0.00% of people
  2. C;TBad1.4x risk of lupusMinor · 1.40% of people
  3. C;CMost notableBad>1.4x risk of lupusWorth knowing · 2.0100% of people

SNPedia records rs2230201 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageT;T 0% C;T 0% C;C 100%
  • European ancestry (Utah)T;T 0% C;T 0% C;C 100%
  • Han Chinese (Beijing)T;T 0% C;T 0% C;C 100%
  • Japanese (Tokyo)T;T 0% C;T 0% C;C 100%
  • Yoruba (Nigeria)T;T 0% C;T 0% C;C 100%

Conditions, medicines and genes

Other C3 SNPs

All C3 SNPs

Notes

From SNPedia

Notes

In ~500 Japanese SLE patients, the (G) allele of rs2230201, a SNP in the C3 gene, is associated with higher risk for systemic lupus erythematosus (SLE). The odds ratio is 1.19 (CI: 1.01-1.41, p=0.038).

Source and license

Adapted from rs2230201 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.