rs7951

A SNP in the C3 gene on chromosome 19. Its most notable genotype is G;G: common in clinvar

Gene
C3
Location
Chr 196,681,980 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
9%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableGoodcommon in clinvarTypical · 0.089% of people
  2. A;GNot rated1.4x risk of lupusTypical · 0.07% of people
  3. A;ANot rated>1.4x risk of lupusTypical · 0.04% of people

SNPedia records rs7951 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 3 HapMap populations.

  • AverageG;G 89% A;G 7% A;A 4%
  • European ancestry (Utah)G;G 94% A;G 5% A;A 2%
  • Han Chinese (Beijing)G;G 91% A;G 9% A;A 0%
  • Japanese (Tokyo)G;G 82% A;G 8% A;A 10%

Conditions, medicines and genes

Other C3 SNPs

All C3 SNPs

Notes

From SNPedia

Notes

In ~500 Japanese SLE patients, the (T) allele of rs7951, a SNP in the C3 gene, is associated with higher risk for systemic lupus erythematosus (SLE). The odds ratio is 1.40 (CI: 1.05-1.86, p=0.016). The mean serum level of the C3 protein was lower in (C;T) and (T;T) genotypes than for individuals with (C;C) genotypes.

Source and license

Adapted from rs7951 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.