rs2236225(A;A)

Slightly (~1.5x) higher risk for Caucasian mothers to give birth to NTD children

Magnitude
1.5Minor
Repute
Bad
Frequency
11%Average of 11 populations
On SNPedia
rs2236225(T;T)Minus strand
Gene
MTHFD1

Frequency

Share of people with A;A in each HapMap population.

  • Mexican ancestry (Los Angeles)36%
  • Gujarati Indian21%
  • European ancestry (Utah)18%
  • Tuscan17%
  • Maasai (Kenya)10%
  • Japanese (Tokyo)5%
  • Luhya (Kenya)4%
  • Yoruba (Nigeria)3%
  • Han Chinese (Beijing)3%
  • African ancestry (Southwest US)2%
  • Chinese (Denver)<1%

Other genotypes of rs2236225

  1. G;GGoodcommon/normalTypical · 0.046% of people
  2. A;GBadPossible increased risk of birth defectsMinor · 1.343% of people

All about rs2236225

Notes

From SNPedia

There is a slightly higher risk (~1.5x at most) for Caucasian mothers with this genotype to give birth to children with neural tube defects; see discussion at rs2236225.

Source and license

Adapted from rs2236225(T;T) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.