rs2236225(A;G)

Possible increased risk of birth defects

Magnitude
1.3Minor
Repute
Bad
Frequency
43%Average of 11 populations
On SNPedia
rs2236225(C;T)Minus strand
Gene
MTHFD1

Frequency

Share of people with A;G in each HapMap population.

  • Maasai (Kenya)56%
  • Gujarati Indian52%
  • European ancestry (Utah)48%
  • Tuscan47%
  • Mexican ancestry (Los Angeles)47%
  • Japanese (Tokyo)42%
  • African ancestry (Southwest US)40%
  • Han Chinese (Beijing)38%
  • Luhya (Kenya)36%
  • Chinese (Denver)34%
  • Yoruba (Nigeria)32%

Other genotypes of rs2236225

  1. G;GGoodcommon/normalTypical · 0.046% of people
  2. A;AMost notableBadSlightly (~1.5x) higher risk for Caucasian mothers to give birth to NTD childrenMinor · 1.511% of people

All about rs2236225

Notes

From SNPedia

Some studies, predominanty amongst Caucasians, have shown that presence of this mutation is associated with a slightly higher risk to give birth to children with neural tube defects; other studies have demonstrated association with heart defects in homozygous offspring - See discussion at rs2236225.

Source and license

Adapted from rs2236225(C;T) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.