rs2282679
A SNP in the GC gene on chromosome 4. Its most notable genotype is G;G: lower vitamin D levels
- Gene
- GC
- Location
- Chr 471,742,666 (GRCh38)
- Highest magnitude
- 1.5Minor
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 22%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs2282679 on the minus strand: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageT;T 65% G;T 31% G;G 4%
- European ancestry (Utah)T;T 52% G;T 43% G;G 4%
- Han Chinese (Beijing)T;T 47% G;T 44% G;G 10%
- Japanese (Tokyo)T;T 56% G;T 39% G;G 5%
- Yoruba (Nigeria)T;T 92% G;T 8% G;G 0%
- African ancestry (Southwest US)T;T 81% G;T 19% G;G 0%
- Chinese (Denver)T;T 53% G;T 37% G;G 10%
- Gujarati IndianT;T 47% G;T 47% G;G 7%
- Luhya (Kenya)T;T 90% G;T 10% G;G 0%
- Mexican ancestry (Los Angeles)T;T 48% G;T 52% G;G 0%
- Maasai (Kenya)T;T 91% G;T 8% G;G <1%
- TuscanT;T 55% G;T 39% G;G 6%
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 130 words
rs2282679, located in the group-specific component (vitamin D binding protein) GC gene on chromosome 4p12, has been linked by several studies to vitamin D serum concentrations. In both studies, the allele associated with lower vitamin D, and thus the potential for vitamin D insufficiency, is rs2282679(C). Carriers of two such alleles have lower vitamin D than carriers of one allele, who in turn on average have lower vitamin D levels than rs2282679(A;A) individuals. A near-perfect proxy (i.e. substitute) for rs2282679 is reported to be rs4588, which was the variant originally used along with rs7041 to define three alternative vitamin D binding protein forms. rs2282679(A) is typically co-inherited with rs4588(C); rs2282679(C) is typically co-inherited with rs4588(A).
Source and license
Adapted from rs2282679 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.