rs4752

A SNP in the GC gene on chromosome 4. Its most notable genotype is A;A: common in complete genomics

Gene
GC
Location
Chr 471,756,849 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
11%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodcommon in complete genomicsTypical · 0.073% of people

SNPedia records rs4752 on the minus strand: (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageA;A 73%
  • European ancestry (Utah)A;A 100%
  • Han Chinese (Beijing)A;A 87%
  • Japanese (Tokyo)A;A 71%
  • Yoruba (Nigeria)A;A 48%
  • African ancestry (Southwest US)A;A 56%
  • Chinese (Denver)A;A 87%
  • Luhya (Kenya)A;A 38%
  • Mexican ancestry (Los Angeles)A;A 88%
  • Maasai (Kenya)A;A 62%
  • TuscanA;A 97%

Other GC SNPs

All GC SNPs

Notes

From SNPedia

Notes

Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway. Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans. Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk.

Source and license

Adapted from rs4752 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.