rs4588

see rs2282679, a near-perfect proxy for rs4588 rs4588(C), the more common allele in most populations, encodes a threonine (Thr) at position 436 in the vitamin D binding protein (VDBP); in older literature, this is numbered as position 420. rs4588(A), the rarer allele, encodes a lysine (Lys) at this position. see discussion at the GC gene for how rs4588 and rs7041 together define three forms of the VDB protein Gene-environment interaction effects on the development of immune responses in the 1st year of life. The genetics of chronic obstructive pulmonary disease. Vitamin D pathway gene polymorphisms, diet, and risk of postmenopausal breast cancer: a nested case-control study. The Gc2 allele of the vitamin D binding protein is associated with a decreased postmenopausal breast cancer risk, independent of the vitamin D status. Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans. Genetic polymorphisms of the vitamin D binding protein and plasma concentrations of 25-hydroxyvitamin D in premenopausal women. A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients. Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach. Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study. A candidate gene association study of 77 polymorphisms in migraine. An evaluation of candidate genes of inflammation and thrombosis in relation to the risk of venous thromboembolism: The Women's Genome Health Study. Associations between common variants in GC and DHCR7/NADSYN1 and vitamin D concentration in Chinese Hans. Genetic and environmental predictors of serum 25-hydroxyvitamin D concentrations among middle-aged and elderly Chinese in Singapore.