rs2287780
A SNP in the MTRR gene on chromosome 5. Its most notable genotype is C;C: common in clinvar
- Gene
- MTRR
- Location
- Chr 57,889,191 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 8%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 85%
- European ancestry (Utah)C;C 95%
- Han Chinese (Beijing)C;C 72%
- Japanese (Tokyo)C;C 70%
- Yoruba (Nigeria)C;C 98%
- African ancestry (Southwest US)C;C 97%
- Chinese (Denver)C;C 73%
- Gujarati IndianC;C 92%
- Luhya (Kenya)C;C 90%
- Mexican ancestry (Los Angeles)C;C 62%
- Maasai (Kenya)C;C 92%
- TuscanC;C 99%
Related
Other MTRR SNPs
- rs1532268T;Tincreased riskWorth knowing
- rs1801394G;G1.4x higher risk for meningiomasWorth knowing
- rs9332G;Gcommon in complete genomicsTypical
- rs10380C;Ccommon in complete genomicsTypical
- rs162036A;Acommon in complete genomicsTypical
- rs1802059G;Gcommon in clinvarTypical
- rs2303080T;Tcommon in clinvarTypical
- rs3776463A;Acommon genotypeTypical
Notes
From SNPedia
Notes
Yasko Methylation Methionine synthase, coded by the MTR gene, has a B12 attached to it. The Methionine synthase takes a methyl group from methyl folate and attaches it to its B12, then it attaches it to a molecule of homocysteine, turning it into methionine, which in turn becomes SAMe. After 1000-2000 times doing this, the B12 gets turned into a useless form, and MTRR turns the B12 back into the useful form so that the molecule of MTR can keep working. The MTRR mutations make this enzyme less active, suggesting a need for more B12.
Source and license
Adapted from rs2287780 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.