rs2303080
A SNP in the MTRR gene on chromosome 5. Its most notable genotype is T;T: common in clinvar
- Gene
- MTRR
- Location
- Chr 57,878,311 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- AncestryDNA
- Minor allele frequency
- 4%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageT;T 89%
- European ancestry (Utah)T;T 94%
- Han Chinese (Beijing)T;T 96%
- Japanese (Tokyo)T;T 66%
- Yoruba (Nigeria)T;T 100%
Related
Other MTRR SNPs
- rs1532268T;Tincreased riskWorth knowing
- rs1801394G;G1.4x higher risk for meningiomasWorth knowing
- rs9332G;Gcommon in complete genomicsTypical
- rs10380C;Ccommon in complete genomicsTypical
- rs162036A;Acommon in complete genomicsTypical
- rs1802059G;Gcommon in clinvarTypical
- rs2287780C;Ccommon in clinvarTypical
- rs3776463A;Acommon genotypeTypical
Notes
From SNPedia
Notes
Yasko Methylation Necessary to regenerate Methyl-B12 for use by MTR. Mutation can cause shortage, suggesting a need for more B12.
Source and license
Adapted from rs2303080 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.