rs2395185

A SNP on chromosome 6. Its most notable genotype is T;T: 9.49x risk of Type 1 Diabetes, but 0.58x lower risk of Ulcerative Colitis.

Gene
None listed
Location
Chr 632,465,390 (GRCh38)
Highest magnitude
3.0Important
Tested on
23andMe, AncestryDNA
Minor allele frequency
29%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GGood1.33x increased risk of Ulcerative Colitis, but much lower Type 1 Diabetes risk.Worth knowing · 2.050% of people
  2. G;TBad2.72x higher risk of Type 1 Diabetes, but 0.88x lower risk of Ulcerative Colitis.Worth knowing · 2.040% of people
  3. T;TMost notableBad9.49x risk of Type 1 Diabetes, but 0.58x lower risk of Ulcerative Colitis.Important · 3.010% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 50% G;T 40% T;T 10%
  • European ancestry (Utah)G;G 34% G;T 46% T;T 21%
  • Han Chinese (Beijing)G;G 39% G;T 48% T;T 13%
  • Japanese (Tokyo)G;G 36% G;T 52% T;T 13%
  • Yoruba (Nigeria)G;G 66% G;T 31% T;T 4%
  • African ancestry (Southwest US)G;G 65% G;T 30% T;T 5%
  • Chinese (Denver)G;G 38% G;T 43% T;T 19%
  • Gujarati IndianG;G 48% G;T 42% T;T 10%
  • Luhya (Kenya)G;G 76% G;T 21% T;T 3%
  • Mexican ancestry (Los Angeles)G;G 39% G;T 52% T;T 9%
  • Maasai (Kenya)G;G 53% G;T 35% T;T 12%
  • TuscanG;G 57% G;T 38% T;T 5%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 130 words

A genome-wide association study using DNA samples from 1,052 individuals with ulcerative colitis and preexisting data from 2,571 controls, all of European ancestry, concluded that this SNP and several others were associated with altered risk for the disease.

G;G

This raises the risk of Ulcerative Colitis (according to 23andMe), but also greatly lowers the risk of Type 1 Diabetes. It may also affect other autoimmune diseases.

G;T

This lowers the risk of Ulcerative Colitis (according to 23andMe), and increases the risk of Type 1 Diabetes.PMID 19837788 It may also affect other autoimmune diseases.

T;T

This lowers the risk of Ulcerative Colitis (according to 23andMe), but has ten times the risk of Type 1 Diabetes.PMID 19837788 It may also affect other autoimmune diseases.

References

Source and license

Adapted from rs2395185 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.