rs2420946

A SNP in the FGFR2 gene on chromosome 10. Its most notable genotype is T;T: 1.64x risk for breast cancer

Gene
FGFR2
Location
Chr 10121,591,810 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
44%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CNot ratedcommonTypical · 0.030% of people
  2. C;TBad1.20x risk for breast cancerWorth knowing · 2.048% of people
  3. T;TMost notableBad1.64x risk for breast cancerWorth knowing · 2.122% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 30% C;T 48% T;T 22%
  • European ancestry (Utah)C;C 32% C;T 43% T;T 25%
  • Han Chinese (Beijing)C;C 37% C;T 45% T;T 18%
  • Japanese (Tokyo)C;C 44% C;T 43% T;T 12%
  • Yoruba (Nigeria)C;C 18% C;T 49% T;T 33%
  • African ancestry (Southwest US)C;C 23% C;T 58% T;T 19%
  • Chinese (Denver)C;C 41% C;T 48% T;T 11%
  • Gujarati IndianC;C 32% C;T 52% T;T 16%
  • Luhya (Kenya)C;C 21% C;T 55% T;T 24%
  • Mexican ancestry (Los Angeles)C;C 30% C;T 46% T;T 25%
  • Maasai (Kenya)C;C 18% C;T 49% T;T 33%
  • TuscanC;C 36% C;T 43% T;T 21%

Conditions, medicines and genes

Other FGFR2 SNPs

All FGFR2 SNPs

Notes

From SNPedia

Notes

This SNP is basically a proxy for SNP rs1219648, which represents the SNP in the FGFR2 gene with the strongest association with breast cancer. Based on a study of 1,049 Chinese breast cancer patients, carriers of risk alleles at three SNPs (rs2981582, rs1219648 and rs2420946) were at 1.36x increased risk for breast cancer (CI: 1.13-1.62, p = 0.001).

Source and license

Adapted from rs2420946 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.