rs3750817

A SNP in the FGFR2 gene on chromosome 10. Its most notable genotype is T;T: 0.64x reduced risk for breast cancer, and higher likelihood of favorable postmenopausal hormone therapy

Gene
FGFR2
Location
Chr 10121,573,063 (GRCh38)
Highest magnitude
2.4Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
34%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CNot ratednormalTypical · 0.053% of people
  2. C;TGood0.78x reduced risk for breast cancerWorth knowing · 2.034% of people
  3. T;TMost notableGood0.64x reduced risk for breast cancer, and higher likelihood of favorable postmenopausal hormone therapyWorth knowing · 2.413% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 53% C;T 34% T;T 13%
  • European ancestry (Utah)C;C 43% C;T 43% T;T 14%
  • Han Chinese (Beijing)C;C 22% C;T 52% T;T 26%
  • Japanese (Tokyo)C;C 20% C;T 50% T;T 30%
  • Yoruba (Nigeria)C;C 97% C;T 3% T;T 0%
  • African ancestry (Southwest US)C;C 91% C;T 9% T;T 0%
  • Chinese (Denver)C;C 17% C;T 53% T;T 30%
  • Gujarati IndianC;C 31% C;T 53% T;T 17%
  • Luhya (Kenya)C;C 94% C;T 6% T;T 0%
  • Mexican ancestry (Los Angeles)C;C 36% C;T 50% T;T 14%
  • Maasai (Kenya)C;C 86% C;T 14% T;T 0%
  • TuscanC;C 45% C;T 43% T;T 12%

Conditions, medicines and genes

Other FGFR2 SNPs

All FGFR2 SNPs

Notes

From SNPedia

Notes

rs3750817 is a SNP in the fibroblast growth factor receptor 2 FGFR2 gene. A study of 2,166 invasive breast cancer cases concluded that carriers of a rs3750817(T) allele had lower risk for cancer, with an estimated per-minor-allele odds ratio of 0.78. Success with hormone therapy to treat postmenopausal symptoms also correlated with the number of rs3750817(T) alleles. Common variation in the fibroblast growth factor receptor 2 gene is not associated with endometriosis risk.

Source and license

Adapted from rs3750817 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.