rs2542052

A SNP in the APOC3 gene on chromosome 11. Its most notable genotype is A;A: Normal (Reference)

Gene
APOC3
Location
Chr 11116,829,268 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
48%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodNormal (Reference)Worth knowing · 2.030% of people
  2. C;CGoodbetter odds of living to 100Worth knowing · 2.020% of people

On SNPedia: (A;A), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 30% C;C 20%
  • European ancestry (Utah)A;A 12% C;C 39%
  • Han Chinese (Beijing)A;A 12% C;C 26%
  • Japanese (Tokyo)A;A 18% C;C 21%
  • Yoruba (Nigeria)A;A 51% C;C 5%
  • African ancestry (Southwest US)A;A 61% C;C 5%
  • Chinese (Denver)A;A 18% C;C 29%
  • Gujarati IndianA;A 32% C;C 19%
  • Luhya (Kenya)A;A 53% C;C 6%
  • Mexican ancestry (Los Angeles)A;A 12% C;C 33%
  • Maasai (Kenya)A;A 49% C;C 10%
  • TuscanA;A 12% C;C 29%

Conditions, medicines and genes

Other APOC3 SNPs

All APOC3 SNPs

Notes

From SNPedia

Notes

This SNP may be related to longevity. One study found that Ashkenazi who lived to age 95 or older are more likely to have two copies of the C allele.

Source and license

Adapted from rs2542052 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.