rs76353203

A SNP in the APOC3 gene on chromosome 11. Its most notable genotype is C;T: rare variant with large positive effect

Gene
APOC3
Location
Chr 11116,830,637 (GRCh38)
Highest magnitude
4.0Very important
Tested on
AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CBadcommon in clinvarTypical · 0.0
  2. C;TMost notableGoodrare variant with large positive effectVery important · 4.0

On SNPedia: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other APOC3 SNPs

All APOC3 SNPs

Notes

From SNPedia

Notes

rs76353203, also known as R19X, is a rare variant in the apolipoprotein C3 APOC3 gene. As reported in two large studies published in 2014, rs76353203 one of several loss of function mutations in the APOC3 gene associated with a >40% lower average triglyceride level in individuals carrying one rs76353203(T) allele and a corresponding decrease in coronary artery disease.

C;C

but the rare allele is beneficial

C;T

This variant of one of several known, rare variants in the APOC3 gene that reduce triglyceride levels and thereby risk for coronary artery disease.

Source and license

Adapted from rs76353203 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.