rs261332

A SNP in the LIPC gene on chromosome 15. Its most notable genotype is A;A: associated with higher HDL cholesterol

Gene
LIPC
Location
Chr 1558,435,126 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
19%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodassociated with higher HDL cholesterolWorth knowing · 2.04% of people
  2. A;GGoodassociated with higher HDL cholesterolWorth knowing · 2.030% of people
  3. G;GGoodcommon in complete genomicsTypical · 0.066% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 4% A;G 30% G;G 66%
  • European ancestry (Utah)A;A 6% A;G 35% G;G 59%
  • Han Chinese (Beijing)A;A 4% A;G 23% G;G 73%
  • Japanese (Tokyo)A;A 7% A;G 51% G;G 42%
  • Yoruba (Nigeria)A;A 5% A;G 38% G;G 57%
  • African ancestry (Southwest US)A;A 5% A;G 35% G;G 60%
  • Chinese (Denver)A;A <1% A;G 20% G;G 79%
  • Gujarati IndianA;A 4% A;G 28% G;G 68%
  • Luhya (Kenya)A;A 4% A;G 29% G;G 67%
  • Mexican ancestry (Los Angeles)A;A 7% A;G 16% G;G 77%
  • Maasai (Kenya)A;A 2% A;G 26% G;G 72%
  • TuscanA;A 3% A;G 25% G;G 72%

Conditions, medicines and genes

Other LIPC SNPs

All LIPC SNPs

Notes

From SNPedia

Notes

rs261332 increases susceptibility to Elevated HDL-Cholesterol for carriers of the A allele A allele is associated with 1.41mg/dl increase in HDL cholesterol (good cholesterol).

Source and license

Adapted from rs261332 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.