rs3825776

A SNP in the LIPC gene on chromosome 15. Its most notable genotype is C;C: >1.3x increased risk for ALS

Gene
LIPC
Location
Chr 1558,454,631 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
42%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TGoodNormal risk for ALSMinor · 1.030% of people
  2. C;TBad1.3x increased risk for ALSMinor · 1.550% of people
  3. C;CMost notableBad>1.3x increased risk for ALSWorth knowing · 2.021% of people
  4. A;ANot ratedNo summary available.Typical · 0.00% of people

SNPedia records rs3825776 on the minus strand: (A;A), (A;G), (G;G), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 30% C;T 50% C;C 21% A;A 0%
  • European ancestry (Utah)T;T 40% C;T 51% C;C 9% A;A 0%
  • Han Chinese (Beijing)T;T 30% C;T 50% C;C 20% A;A 0%
  • Japanese (Tokyo)T;T 18% C;T 60% C;C 22% A;A 0%
  • Yoruba (Nigeria)T;T 26% C;T 59% C;C 16% A;A 0%
  • African ancestry (Southwest US)T;T 40% C;T 46% C;C 14% A;A 0%
  • Chinese (Denver)T;T 19% C;T 52% C;C 28% A;A 0%
  • Gujarati IndianT;T 43% C;T 43% C;C 15% A;A 0%
  • Luhya (Kenya)T;T 26% C;T 51% C;C 24% A;A 0%
  • Mexican ancestry (Los Angeles)T;T 17% C;T 47% C;C 36% A;A 0%
  • Maasai (Kenya)T;T 21% C;T 49% C;C 31% A;A 0%
  • TuscanT;T 46% C;T 42% C;C 12% A;A 0%

Other LIPC SNPs

All LIPC SNPs

Notes

From SNPedia

Notes

rs3825776, a SNP in the region of the LIPC gene on chromosome 15, has been associated with the sporadic form of ALS (Lou Gehrig's disease) in a study of 1000+ European patients. The odds ratio for the risk allele rs3825776(G) is 1.34 (CI: 1.12 - 1.46).

Source and license

Adapted from rs3825776 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.