rs267607161
A SNP in the TTR gene on chromosome 18. Its most notable genotype is G;T: TTR-related familial amyloid polyneuropathy
- Gene
- TTR
- Location
- Chr 1831,598,580 (GRCh38)
- Highest magnitude
- 4.0Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- G;GGoodcommon in clinvar
- G;TMost notableBadTTR-related familial amyloid polyneuropathy
On SNPedia: (G;G), (G;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other TTR SNPs
- rs11541790C;TTTR-related amyloidosisVery important
- rs11541796A;GTTR-related amyloidosisVery important
- rs28933979A;GTTR-related amyloidosisVery important
- rs76992529A;GTTR-related amyloidosisVery important
- rs79977247C;TTTR-related amyloidosisVery important
- rs104894664A;GTTR-related amyloidosisVery important
- rs104894665C;TTTR-related amyloidosisVery important
- rs121918068A;TTTR-related amyloidosisVery important
Notes
From SNPedia
Notes
aka c.349G>T (p.Ala117Ser or A117S; however, commonly also referred to in the literature as Ala97Ser or A97S) This variant is reported to be the most common TTR gene mutation among ethnic Chinese Malaysians with transthyretin familial amyloid polyneuropathy.
G;T
see links via main rs-page
Source and license
Adapted from rs267607161 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.