rs281865117
A SNP in the SACS gene on chromosome 13. Its most notable genotype is -;-: neurodegenerative disorder (ARSACS)
- Gene
- SACS
- Location
- Chr 1323,335,032 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- -;-Most notableBadneurodegenerative disorder (ARSACS)
- -;ABadcarrier of a neurodegenerative disorder (ARSACS) mutation
- A;AGoodcommon in clinvar
SNPedia records rs281865117 on the minus strand: (-;-), (-;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other SACS SNPs
- rs137853016G;Gneurodegenerative disorder (ARSACS)Very important
- rs137853017G;Gneurodegenerative disorder (ARSACS)Very important
- rs137853018G;Gneurodegenerative disorder (ARSACS)Very important
- rs137853019G;Gneurodegenerative disorder (ARSACS)Very important
- rs281865118A;Aneurodegenerative disorder (ARSACS)Very important
- rs606231163G;Gneurodegenerative disorder (ARSACS)Very important
- rs2031640A;Acommon on affy axiom dataTypical
- rs4770433A;Acommon in clinvarTypical
Notes
From SNPedia
Notes
c.8844delT (p.Ile2949Phefs) 23andMe name: i5012578
-;-
see SACS gene and ClinVar (via sidebar)
-;A
Unaffected in absence of another mutation in the SACS gene.
Source and license
Adapted from rs281865117 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.