rs281875251
A SNP in the F11 gene on chromosome 4. Its most notable genotype is T;T: Factor XI deficiency
- Gene
- F11
- Location
- Chr 4186,288,525 (GRCh38)
- Highest magnitude
- 5.0Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- G;GGoodcommon in clinvar
- G;TBadcarrier of factor XI mutation
- T;TMost notableBadFactor XI deficiency
On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other F11 SNPs
- rs28934608T;TFactor XI deficiencyVery important
- rs121965063T;TFactor XI deficiencyVery important
- rs121965064C;CFactor XI deficiencyVery important
- rs121965066A;AFactor XI deficiencyVery important
- rs121965067A;AFactor XI deficiencyVery important
- rs121965068T;TFactor XI deficiencyVery important
- rs121965069C;CFactor XI deficiencyVery important
- rs121965071T;TFactor XI deficiencyVery important
Notes
From SNPedia
Notes
aka c.1789G>T (p.Glu597Ter) and also c.1789G>A (p.Glu597Lys); the former is pathogenic in ClinVar for Factor XI deficiency, but the latter is of uncertain significance note that 23andMe tests the c.1789G>A VUS under the name i6009888
G;T
Usually not affected in absence of a second F11 gene mutation
Source and license
Adapted from rs281875251 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.