rs28933680
A SNP in the F8 gene on chromosome X. Its most notable genotype is C;C: Hemophilia A (severity varies)
- Gene
- F8
- Location
- Chr X154,904,493 (GRCh38)
- Highest magnitude
- 5.5Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;GGoodcommon in clinvar
- C;GBadCarrier of a Hemophilia A mutation
- C;CMost notableBadHemophilia A (severity varies)
SNPedia records rs28933680 on the minus strand: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other F8 SNPs
- rs2228152A;AHemophilia A (severity varies)Very important
- rs28933668T;THemophilia A (severity varies)Very important
- rs28933669G;GHemophilia A (severity varies)Very important
- rs28933670C;CHemophilia A (severity varies)Very important
- rs28933671C;CHemophilia A (severity varies)Very important
- rs28933672A;AHemophilia A (severity varies)Very important
- rs28933674T;THemophilia A (severity varies)Very important
- rs28933675A;AHemophilia A (severity varies)Very important
Notes
From SNPedia
Notes
C;G
X-linked recessive, so females are generally unaffected in the absence of a second F8 gene mutation, however some females may experience clotting issues.
Source and license
Adapted from rs28933680 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.