rs33995883
A SNP in the LRRK2 gene on chromosome 12. Its most notable genotype is A;G: Slight (1.8x) increase in risk for Crohn's disease
- Gene
- LRRK2
- Location
- Chr 1240,346,884 (GRCh38)
- Highest magnitude
- 1.8Minor
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (A;A), (A;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other LRRK2 SNPs
- rs33939927A;CParkinson's disease mutation, adult-onsetVery important
- rs34805604A;GParkinson's disease mutation, adult-onsetVery important
- rs34995376A;GParkinson's disease mutation, adult-onsetVery important
- rs35801418A;GParkinson's disease mutation, adult-onsetVery important
- rs35808389A;GParkinson's disease mutation, adult-onsetVery important
- rs35870237C;TParkinson's disease mutation, adult-onsetVery important
- rs74163686A;CParkinson's disease mutation, adult-onsetVery important
- rs281865052A;GParkinson's disease mutation, adult-onsetVery important
Notes
From SNPedia
Notes
rs33995883, also known as c.6241A>G, p.Asn2081Asp and N2081D, represents a variant in the LRKK2 gene on chromosome 12. The minor allele of this SNP was initially reported as potentially associated with Parkinson's disease; however, more recent reviews as well as the current annotation in ClinVar all conclude it is benign (at least with respect to Parkinson's). In 2018, a study of 2,000 patients with Crohn's disease found somewhat increased (~2x) risk for the disorder to be associated with rs33995883(G).
A;G
see discussion on main rs-page
Source and license
Adapted from rs33995883 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.