rs363815
A SNP in the FBN1 gene on chromosome 15. Its most notable genotype is A;G: Marfan syndrome mutation
- Gene
- FBN1
- Location
- Chr 1548,437,370 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- 23andMe, FamilyTreeDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs363815 on the minus strand: (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 2 HapMap populations.
- AverageA;G 0% A;A 100%
- European ancestry (Utah)A;G 0% A;A 100%
- Yoruba (Nigeria)A;G 0% A;A 100%
Related
Other FBN1 SNPs
- rs25404C;TFamilial thoracic aortic aneurysms and dissections (FTAAD)Very important
- rs140603C;GFamilial thoracic aortic aneurysms and dissections (FTAAD)Very important
- rs140630A;GFamilial thoracic aortic aneurysms and dissections (FTAAD)Very important
- rs111231312A;GFamilial thoracic aortic aneurysms and dissections (FTAAD)Very important
- rs111687884A;GFamilial thoracic aortic aneurysms and dissections (FTAAD)Very important
- rs112645512A;GFamilial thoracic aortic aneurysms and dissections (FTAAD)Very important
- rs112728248C;TFamilial thoracic aortic aneurysms and dissections (FTAAD)Very important
- rs112989722C;GFamilial thoracic aortic aneurysms and dissections (FTAAD)Very important
Notes
From SNPedia
Notes
aka c.6331T>C (p.Cys2111Arg or C2111R)
A;G
see links and text via main rs-page
Source and license
Adapted from rs363815 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.