rs3758580
A SNP in the CYP2C19 gene on chromosome 10. Its most notable genotype is C;C: common/normal
- Gene
- CYP2C19
- Location
- Chr 1094,842,865 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageC;C 63%
- European ancestry (Utah)C;C 77%
- Han Chinese (Beijing)C;C 49%
- Japanese (Tokyo)C;C 50%
- Yoruba (Nigeria)C;C 76%
Related
Other CYP2C19 SNPs
- rs4244285A;Apoor metabolizer of several popular medicines; patients prescribed Plavix get less benefit, and have higher risk for adverse cardiovascular eventsVery important
- rs6413438T;TCYP2C19*10 homozygoteImportant
- rs41291556C;CCYP2C19*8 homozygoteImportant
- rs56337013T;TCYP2C19*5 homozygoteImportant
- rs28399504G;Gpoor metabolizerWorth knowing
- rs4986893A;Apoor metabolizer of several commonly prescribed drugsWorth knowing
- rs12248560C;TCYP2C19*17 ultra fast metabolizer; drug metabolism effects; also 0.77x decreased breast cancer riskWorth knowing
- rs3758581A;ACYP2C19 V331I homozygoteTypical
Source and license
Adapted from rs3758580 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.