rs3758581
A SNP in the CYP2C19 gene on chromosome 10. Its most notable genotype is A;A: CYP2C19 V331I homozygote
- Gene
- CYP2C19
- Location
- Chr 1094,842,866 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 4%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableNot ratedCYP2C19 V331I homozygote
- A;GNot ratedcarrier of one CYP2C19 V331I allele
- G;GGoodnormal
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageA;A 1% A;G 9% G;G 90%
- European ancestry (Utah)A;A 0% A;G 9% G;G 91%
- Han Chinese (Beijing)A;A 2% A;G 9% G;G 89%
- Japanese (Tokyo)A;A 2% A;G 16% G;G 82%
- Yoruba (Nigeria)A;A 0% A;G 0% G;G 100%
Related
Other CYP2C19 SNPs
- rs4244285A;Apoor metabolizer of several popular medicines; patients prescribed Plavix get less benefit, and have higher risk for adverse cardiovascular eventsVery important
- rs6413438T;TCYP2C19*10 homozygoteImportant
- rs41291556C;CCYP2C19*8 homozygoteImportant
- rs56337013T;TCYP2C19*5 homozygoteImportant
- rs28399504G;Gpoor metabolizerWorth knowing
- rs4986893A;Apoor metabolizer of several commonly prescribed drugsWorth knowing
- rs12248560C;TCYP2C19*17 ultra fast metabolizer; drug metabolism effects; also 0.77x decreased breast cancer riskWorth knowing
- rs3758580C;Ccommon/normalTypical
Notes
From SNPedia
Notes
The rs3758581(A) SNP defines a CYP2C19 allele known as V331I. Analysis of 50 SNPs in CYP2D6, CYP2C19, CYP2C9, CYP3A4 and CYP1A2 by MALDI-TOF mass spectrometry in Chinese Han population.
Source and license
Adapted from rs3758581 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.