rs4986893
A SNP in the CYP2C19 gene on chromosome 10. Its most notable genotype is A;A: poor metabolizer of several commonly prescribed drugs
- Gene
- CYP2C19
- Location
- Chr 1094,780,653 (GRCh38)
- Highest magnitude
- 2.1Worth knowing
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 1%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableNot ratedpoor metabolizer of several commonly prescribed drugs
- A;GNot ratedcarrier of a CYP2C19*3 allele, a "slow metabolizer" allele
- G;GGoodnormal
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other CYP2C19 SNPs
- rs4244285A;Apoor metabolizer of several popular medicines; patients prescribed Plavix get less benefit, and have higher risk for adverse cardiovascular eventsVery important
- rs6413438T;TCYP2C19*10 homozygoteImportant
- rs41291556C;CCYP2C19*8 homozygoteImportant
- rs56337013T;TCYP2C19*5 homozygoteImportant
- rs28399504G;Gpoor metabolizerWorth knowing
- rs12248560C;TCYP2C19*17 ultra fast metabolizer; drug metabolism effects; also 0.77x decreased breast cancer riskWorth knowing
- rs3758580C;Ccommon/normalTypical
- rs3758581A;ACYP2C19 V331I homozygoteTypical
Genosets
- Gs152CYP2C19 Poor MetabolizerImportant
- Gs151CYP2C19 Intermediate MetabolizerImportant
- Gs150CYP2C19 normal/rapid metabolizer (most likely)Minor
Genosets combine several genotypes. Twofold checks them in your report.
Notes
From SNPedia
Notes
rs4986893 is a SNP in the CYP2C19 gene, potentially encoding the CYP2C19*3 variant. This variant has been linked to poor metabolism of compounds like mephenytoin as well as proguanil, and it therefore has implications for malaria prophylaxis. PMID 7969038, PMID 9093256 The risk allele is rs4986893(A). As a nonfunctioning CYP2C19, this variant would be expected to be a poor metabolizer of several commonly prescribed drugs, including anti-ulcer drugs like omeprazole (trade names Losec and Prilosec), esomeprazole (trade name Nexium), and lansoprazole (Prevacid). Clopidogrel Efficacy
Source and license
Adapted from rs4986893 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.