rs3814637
A SNP in the CYP2C19 gene on chromosome 10. Its most notable genotype is C;C.
- Gene
- CYP2C19
- Location
- Chr 1094,761,288 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe
- Minor allele frequency
- 8%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 3 HapMap populations.
- AverageC;C 77%
- Han Chinese (Beijing)C;C 79%
- Japanese (Tokyo)C;C 76%
- Yoruba (Nigeria)C;C 76%
Related
Conditions, medicines and genes
Other CYP2C19 SNPs
- rs4244285A;Apoor metabolizer of several popular medicines; patients prescribed Plavix get less benefit, and have higher risk for adverse cardiovascular eventsVery important
- rs6413438T;TCYP2C19*10 homozygoteImportant
- rs41291556C;CCYP2C19*8 homozygoteImportant
- rs56337013T;TCYP2C19*5 homozygoteImportant
- rs28399504G;Gpoor metabolizerWorth knowing
- rs4986893A;Apoor metabolizer of several commonly prescribed drugsWorth knowing
- rs12248560C;TCYP2C19*17 ultra fast metabolizer; drug metabolism effects; also 0.77x decreased breast cancer riskWorth knowing
- rs3758580C;Ccommon/normalTypical
Notes
From SNPedia
Notes
rs3814637 represents an intronic variant in the CYP2C19 gene. Although found within several CYP2C19 star alleles (CYP2C19*1.004, CYP2C19*1.005, and CYP2C19*15.001) that have normal function, the minor (T) allele of rs3814637 is associated with significantly lower maintenance doses of warfarin among UK BioBank participants. Association of warfarin dose with genes involved in its action and metabolism. The largest prospective warfarin-treated cohort supports genetic forecasting.
Source and license
Adapted from rs3814637 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.