rs397516463
A SNP in the TNNT2 gene on chromosome 1. Its most notable genotype is A;G: Familial hypertrophic cardiomyopathy (possible)
- Gene
- TNNT2
- Location
- Chr 1201,364,369 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;GGoodcommon in clinvar
- A;GMost notableBadFamilial hypertrophic cardiomyopathy (possible)
SNPedia records rs397516463 on the minus strand: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other TNNT2 SNPs
- rs74315379C;THypertrophic CardiomyopathyVery important
- rs121964856A;GHypertrophic CardiomyopathyVery important
- rs45525839C;GDilated cardiomyopathyVery important
- rs111377893A;CFamilial Hypertrophic CardiomyopathyVery important
- rs121964858A;TFamilial Hypertrophic CardiomyopathyVery important
- rs376923877G;TFamilial Hypertrophic CardiomyopathyVery important
- rs397516454A;CDilated cardiomyopathyVery important
- rs397516456A;GFamilial Hypertrophic CardiomyopathyVery important
Notes
From SNPedia
Notes
The rare minor allele of this variant is reported to be pathogenic/likely pathogenic for familial hypertrophic cardiomyopathy (HCM), according to .
A;G
see discussion at rs397516463
Source and license
Adapted from rs397516463 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.