rs398122885
A SNP in the TGFB2 gene on chromosome 1. Its most notable genotype is A;C: Loeys-Dietz Syndrome
- Gene
- TGFB2
- Location
- Chr 1218,434,381 (GRCh38)
- Highest magnitude
- 7.0Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;CMost notableBadLoeys-Dietz Syndrome
- C;CGoodcommon in clinvar
On SNPedia: (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other TGFB2 SNPs
- rs863223797-;CThoracic aortic aneurysm (potential causative mutation)Very important
- rs387907278A;CLoeys-Dietz SyndromeVery important
- rs398122884-;ACAATLoeys-Dietz SyndromeVery important
- rs730880221C;TLoeys-Dietz SyndromeVery important
- rs869025533-;ALoeys-Dietz SyndromeVery important
- rs991967A;Acommon in clinvarTypical
Source and license
Adapted from rs398122885 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.