rs398123690
A SNP in the SDHB gene on chromosome 1. Its most notable genotype is -;G: Hereditary PGL/PCC Syndrome
- Gene
- SDHB
- Location
- Chr 117,044,848 (GRCh38)
- Highest magnitude
- 6.2Very important
- Tested on
- AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- -;-Goodcommon in clinvar
- -;GMost notableBadHereditary PGL/PCC Syndrome
- -;CCBadHereditary PGL/PCC Syndrome
- CC;CCGoodcommon/normal
SNPedia records rs398123690 on the minus strand: (-;-), (-;C), (-;CC), (CC;CC). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other SDHB SNPs
- rs74315366A;GHereditary PGL/PCC SyndromeVery important
- rs74315367C;GHereditary PGL/PCC SyndromeVery important
- rs74315368C;THereditary PGL/PCC SyndromeVery important
- rs74315369A;GHereditary PGL/PCC SyndromeVery important
- rs74315370C;GHereditary PGL/PCC SyndromeVery important
- rs74315371C;THereditary PGL/PCC SyndromeVery important
- rs74315372G;THereditary PGL/PCC SyndromeVery important
- rs138996609A;GHereditary PGL/PCC SyndromeVery important
Notes
From SNPedia
Notes
aka c.112delG as well as c.111_112dupGG; both are considered in ClinVar to be pathogenic, either for pheochromocytomas or a hereditary cancer predisposing syndrome, respectively
Source and license
Adapted from rs398123690 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.