rs4273077(A;G)

Possibly slight 1.09x risk for development of MGUS

Magnitude
1.0Minor
Repute
Bad
Frequency
32%Average of 11 populations
On SNPedia
rs4273077(A;G)
Gene
TNFRSF13B

Frequency

Share of people with A;G in each HapMap population.

  • Chinese (Denver)56%
  • Han Chinese (Beijing)50%
  • Japanese (Tokyo)50%
  • Gujarati Indian33%
  • Mexican ancestry (Los Angeles)32%
  • Yoruba (Nigeria)29%
  • Maasai (Kenya)21%
  • Tuscan21%
  • European ancestry (Utah)21%
  • African ancestry (Southwest US)19%
  • Luhya (Kenya)18%

Other genotypes of rs4273077

  1. A;AGoodNormal risk for development of MGUSMinor · 1.061% of people
  2. G;GMost notableBad3.57x increased risk of MGUSWorth knowing · 2.07% of people

All about rs4273077

Notes

From SNPedia

Very slightly increased risk for the development of MGUS (Monoclonal Gammopathy of Uncertain Significance). 95% CI .78-1.51. Plausible as the homozygote is more statistically significant and higher risk in the same study. Thus, the major, protective A allele can probably be thought of as acting in a dominant fashion in reducing risk of the development of MGUS. This genotype may be benign - any additional risk conferred is likely minimal.

Source and license

Adapted from rs4273077(A;G) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.