rs4273077(G;G)

3.57x increased risk of MGUS

Magnitude
2.0Worth knowing
Repute
Bad
Frequency
7%Average of 11 populations
On SNPedia
rs4273077(G;G)
Gene
TNFRSF13B

Frequency

Share of people with G;G in each HapMap population.

  • Japanese (Tokyo)23%
  • Chinese (Denver)22%
  • Han Chinese (Beijing)19%
  • African ancestry (Southwest US)4%
  • Luhya (Kenya)3%
  • Yoruba (Nigeria)2%
  • Mexican ancestry (Los Angeles)2%
  • Maasai (Kenya)1%
  • Gujarati Indian1%
  • Tuscan1%
  • European ancestry (Utah)<1%

Other genotypes of rs4273077

  1. A;AGoodNormal risk for development of MGUSMinor · 1.061% of people
  2. A;GBadPossibly slight 1.09x risk for development of MGUSMinor · 1.032% of people

All about rs4273077

Notes

From SNPedia

This genotype confers an increased risk of the development of MGUS (Monoclonal Gammopathy of Uncertain Significance). OR=3.57 95% CI=1.67-7.65. The G allele is the minor allele and the risk allele, and appears to function in a recessive manner in increasing risk, as the AG heterozygote has nearly the same risk as the AA homozygote.

Source and license

Adapted from rs4273077(G;G) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.