rs4273077

A SNP in the TNFRSF13B gene on chromosome 17. Its most notable genotype is G;G: 3.57x increased risk of MGUS

Gene
TNFRSF13B
Location
Chr 1716,945,825 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
22%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodNormal risk for development of MGUSMinor · 1.061% of people
  2. A;GBadPossibly slight 1.09x risk for development of MGUSMinor · 1.032% of people
  3. G;GMost notableBad3.57x increased risk of MGUSWorth knowing · 2.07% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 61% A;G 32% G;G 7%
  • European ancestry (Utah)A;A 79% A;G 21% G;G <1%
  • Han Chinese (Beijing)A;A 31% A;G 50% G;G 19%
  • Japanese (Tokyo)A;A 28% A;G 50% G;G 23%
  • Yoruba (Nigeria)A;A 69% A;G 29% G;G 2%
  • African ancestry (Southwest US)A;A 77% A;G 19% G;G 4%
  • Chinese (Denver)A;A 22% A;G 56% G;G 22%
  • Gujarati IndianA;A 66% A;G 33% G;G 1%
  • Luhya (Kenya)A;A 79% A;G 18% G;G 3%
  • Mexican ancestry (Los Angeles)A;A 67% A;G 32% G;G 2%
  • Maasai (Kenya)A;A 78% A;G 21% G;G 1%
  • TuscanA;A 78% A;G 21% G;G 1%

Other TNFRSF13B SNPs

All TNFRSF13B SNPs

Notes

From SNPedia

Show notes, about 160 words

A;A

This was defined as an OR of 1.0 for the development of MGUS (Monoclonal Gammopathy of Uncertain Significance). A is the major allele and not the risk allele.

A;G

Very slightly increased risk for the development of MGUS (Monoclonal Gammopathy of Uncertain Significance). 95% CI .78-1.51. Plausible as the homozygote is more statistically significant and higher risk in the same study. Thus, the major, protective A allele can probably be thought of as acting in a dominant fashion in reducing risk of the development of MGUS. This genotype may be benign - any additional risk conferred is likely minimal.

G;G

This genotype confers an increased risk of the development of MGUS (Monoclonal Gammopathy of Uncertain Significance). OR=3.57 95% CI=1.67-7.65. The G allele is the minor allele and the risk allele, and appears to function in a recessive manner in increasing risk, as the AG heterozygote has nearly the same risk as the AA homozygote.

Source and license

Adapted from rs4273077 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.