rs4363657

A SNP in the SLCO1B1 gene on chromosome 12. Its most notable genotype is C;C: 17x increased myopathy risk for statin users

Gene
SLCO1B1
Location
Chr 1221,215,788 (GRCh38)
Highest magnitude
4.0Very important
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
25%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBad17x increased myopathy risk for statin usersVery important · 4.08% of people
  2. C;TBad4.5x increased myopathy risk for statin usersWorth knowing · 2.131% of people
  3. T;TGoodnormalTypical · 0.061% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 8% C;T 31% T;T 61%
  • European ancestry (Utah)C;C <1% C;T 31% T;T 68%
  • Han Chinese (Beijing)C;C 23% C;T 44% T;T 33%
  • Japanese (Tokyo)C;C 18% C;T 43% T;T 39%
  • Yoruba (Nigeria)C;C 1% C;T 25% T;T 74%
  • African ancestry (Southwest US)C;C 5% C;T 32% T;T 63%
  • Chinese (Denver)C;C 28% C;T 41% T;T 32%
  • Gujarati IndianC;C 0% C;T 13% T;T 87%
  • Luhya (Kenya)C;C 2% C;T 27% T;T 72%
  • Mexican ancestry (Los Angeles)C;C 2% C;T 18% T;T 81%
  • Maasai (Kenya)C;C 5% C;T 28% T;T 68%
  • TuscanC;C 4% C;T 37% T;T 59%

Conditions, medicines and genes

Other SLCO1B1 SNPs

All SLCO1B1 SNPs

Notes

From SNPedia

Show notes, about 130 words

rs4363657 is a SNP in the SLCO1B1 gene, a gene which encodes a protein involved in the liver's uptake of certain drugs, including the statins used to lower cholesterol levels. rs4363657 in nearly complete linkage disequilibrium with rs4149056 SNP (r 2 =0.97), which has been linked to statin metabolism. rs4149056(C) odds ratio for myopathy among 20,000 individuals taking either 40 or 80mg of simvastatin daily was 4.5 (CI: 2.6-7.7) per copy of the C allele, and 16.9 (CI: 4.7-61.1) in (C;C) as compared with (T;T) homozygotes. See also rs4149056 for a more detailed description of the effect of SLCO1B1 gene SNPs on the metabolism of many drugs. SLCO1B1 genetic variant associated with statin-induced myopathy: a proof-of-concept study using the clinical practice research datalink

Source and license

Adapted from rs4363657 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.