rs4489954(T;T)

>0.69x risk of developing restless legs syndrome

Magnitude
1.8Minor
Repute
Good
Frequency
25%Average of 11 populations
On SNPedia
rs4489954(T;T)
Gene
MAP2K5

Frequency

Share of people with T;T in each HapMap population.

  • Chinese (Denver)50%
  • Japanese (Tokyo)49%
  • Han Chinese (Beijing)47%
  • Mexican ancestry (Los Angeles)38%
  • Gujarati Indian28%
  • Tuscan13%
  • African ancestry (Southwest US)12%
  • Maasai (Kenya)12%
  • Yoruba (Nigeria)11%
  • Luhya (Kenya)10%
  • European ancestry (Utah)5%

Other genotypes of rs4489954

  1. G;GBadNormal risk of developing restless legs syndromeMinor · 1.030% of people
  2. G;TGood0.69x risk risk of developing restless legs syndromeMinor · 1.545% of people

All about rs4489954

Notes

From SNPedia

But no replication despite being several years since this was first reported

Source and license

Adapted from rs4489954(T;T) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.