rs4489954

A SNP in the MAP2K5 gene on chromosome 15. Its most notable genotype is T;T: >0.69x risk of developing restless legs syndrome

Gene
MAP2K5
Location
Chr 1567,779,737 (GRCh38)
Highest magnitude
1.8Minor
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
46%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GBadNormal risk of developing restless legs syndromeMinor · 1.030% of people
  2. G;TGood0.69x risk risk of developing restless legs syndromeMinor · 1.545% of people
  3. T;TMost notableGood>0.69x risk of developing restless legs syndromeMinor · 1.825% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 30% G;T 45% T;T 25%
  • European ancestry (Utah)G;G 50% G;T 46% T;T 5%
  • Han Chinese (Beijing)G;G 7% G;T 46% T;T 47%
  • Japanese (Tokyo)G;G 10% G;T 42% T;T 49%
  • Yoruba (Nigeria)G;G 35% G;T 54% T;T 11%
  • African ancestry (Southwest US)G;G 37% G;T 51% T;T 12%
  • Chinese (Denver)G;G 10% G;T 40% T;T 50%
  • Gujarati IndianG;G 28% G;T 45% T;T 28%
  • Luhya (Kenya)G;G 51% G;T 39% T;T 10%
  • Mexican ancestry (Los Angeles)G;G 14% G;T 48% T;T 38%
  • Maasai (Kenya)G;G 42% G;T 46% T;T 12%
  • TuscanG;G 48% G;T 39% T;T 13%

Conditions, medicines and genes

Other MAP2K5 SNPs

All MAP2K5 SNPs

Notes

From SNPedia

Notes

rs4489954, a SNP located in a region of chromosome 15q, has been linked to a lower frequency of restless legs syndrome, a common sleep disorder, with an overall odds ratio of 0.69 (CI: 0.69-0.82) for the (T) minor allele.

T;T

But no replication despite being several years since this was first reported

Source and license

Adapted from rs4489954 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.