rs3784709

A SNP in the MAP2K5 gene on chromosome 15. Its most notable genotype is T;T: >0.71x risk of developing restless legs syndrome

Gene
MAP2K5
Location
Chr 1567,779,937 (GRCh38)
Highest magnitude
1.8Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
47%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CBadNormal risk of developing restless legs syndromeMinor · 1.031% of people
  2. C;TGood0.71x risk of developing restless legs syndromeMinor · 1.544% of people
  3. T;TMost notableGood>0.71x risk of developing restless legs syndromeMinor · 1.825% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 31% C;T 44% T;T 25%
  • European ancestry (Utah)C;C 47% C;T 48% T;T 5%
  • Han Chinese (Beijing)C;C 7% C;T 46% T;T 47%
  • Japanese (Tokyo)C;C 10% C;T 45% T;T 45%
  • Yoruba (Nigeria)C;C 37% C;T 51% T;T 12%
  • African ancestry (Southwest US)C;C 42% C;T 40% T;T 18%
  • Chinese (Denver)C;C 10% C;T 40% T;T 50%
  • Gujarati IndianC;C 31% C;T 44% T;T 26%
  • Luhya (Kenya)C;C 48% C;T 37% T;T 15%
  • Mexican ancestry (Los Angeles)C;C 14% C;T 47% T;T 40%
  • Maasai (Kenya)C;C 51% C;T 41% T;T 8%
  • TuscanC;C 46% C;T 41% T;T 13%

Conditions, medicines and genes

Other MAP2K5 SNPs

All MAP2K5 SNPs

Notes

From SNPedia

Notes

rs3784709, a SNP located in a region of chromosome 15q, has been linked to a lower frequency of restless legs syndrome, a common sleep disorder, with an overall odds ratio of 0.71 (CI: 0.60-0.83) for the (T) minor allele.

T;T

But no replication despite being several years since this was first reported

Source and license

Adapted from rs3784709 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.