rs12593813

A SNP in the MAP2K5 gene on chromosome 15. Its most notable genotype is A;A: <0.71x risk for restless legs

Gene
MAP2K5
Location
Chr 1567,744,514 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
45%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGood<0.71x risk for restless legsWorth knowing · 2.037% of people
  2. A;GGood0.71x risk for restless legsMinor · 1.545% of people
  3. G;GBadnormal risk of restless leg syndromeMinor · 1.019% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 37% A;G 45% G;G 19%
  • European ancestry (Utah)A;A 5% A;G 50% G;G 46%
  • Han Chinese (Beijing)A;A 37% A;G 53% G;G 10%
  • Japanese (Tokyo)A;A 43% A;G 44% G;G 12%
  • Yoruba (Nigeria)A;A 67% A;G 30% G;G 3%
  • African ancestry (Southwest US)A;A 40% A;G 51% G;G 9%
  • Chinese (Denver)A;A 38% A;G 45% G;G 17%
  • Gujarati IndianA;A 28% A;G 41% G;G 32%
  • Luhya (Kenya)A;A 51% A;G 45% G;G 5%
  • Mexican ancestry (Los Angeles)A;A 40% A;G 50% G;G 10%
  • Maasai (Kenya)A;A 39% A;G 43% G;G 19%
  • TuscanA;A 15% A;G 41% G;G 45%

Conditions, medicines and genes

Other MAP2K5 SNPs

All MAP2K5 SNPs

Notes

From SNPedia

Notes

rs12593813, a SNP located in a region of chromosome 15q, has been linked to a lower frequency of restless legs syndrome, a common sleep disorder, with an overall odds ratio of 0.71 (CI: 0.60-0.83) for the (A) minor allele. Restless Legs Syndrome: Preliminary Research

Source and license

Adapted from rs12593813 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.