rs1026732

A SNP in the MAP2K5 gene on chromosome 15. Its most notable genotype is A;A: <0.70x risk for restless legs

Gene
MAP2K5
Location
Chr 1567,802,747 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
49%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGood<0.70x risk for restless legsWorth knowing · 2.027% of people
  2. A;GGood0.70x risk for restless legsMinor · 1.545% of people
  3. G;GBadnormal risk of restless leg syndromeMinor · 1.028% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 27% A;G 45% G;G 28%
  • European ancestry (Utah)A;A 5% A;G 48% G;G 47%
  • Han Chinese (Beijing)A;A 48% A;G 47% G;G 5%
  • Japanese (Tokyo)A;A 52% A;G 38% G;G 10%
  • Yoruba (Nigeria)A;A 20% A;G 52% G;G 27%
  • African ancestry (Southwest US)A;A 25% A;G 42% G;G 33%
  • Chinese (Denver)A;A 48% A;G 42% G;G 10%
  • Gujarati IndianA;A 27% A;G 44% G;G 30%
  • Luhya (Kenya)A;A 16% A;G 49% G;G 36%
  • Mexican ancestry (Los Angeles)A;A 38% A;G 48% G;G 14%
  • Maasai (Kenya)A;A 10% A;G 42% G;G 48%
  • TuscanA;A 14% A;G 41% G;G 46%

Conditions, medicines and genes

Other MAP2K5 SNPs

All MAP2K5 SNPs

Notes

From SNPedia

Notes

rs1026732, a SNP located in a region of chromosome 15q, has been linked to a lower frequency of restless legs syndrome, a common sleep disorder, with an overall odds ratio of 0.70 (CI: 0.59-0.82) for the (A) minor allele.

Source and license

Adapted from rs1026732 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.