rs2241423

A SNP in the MAP2K5 gene on chromosome 15. Its most notable genotype is A;A: 0.79 decreased risk for obesity

Gene
MAP2K5
Location
Chr 1567,794,500 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
40%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGood0.79 decreased risk for obesityWorth knowing · 2.020% of people
  2. A;GGood0.79 decreased risk for obesityWorth knowing · 2.043% of people
  3. G;GBadNormal risk for obesityMinor · 1.037% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 20% A;G 43% G;G 37%
  • European ancestry (Utah)A;A 3% A;G 35% G;G 62%
  • Han Chinese (Beijing)A;A 39% A;G 46% G;G 15%
  • Japanese (Tokyo)A;A 37% A;G 43% G;G 20%
  • Yoruba (Nigeria)A;A 18% A;G 51% G;G 31%
  • African ancestry (Southwest US)A;A 19% A;G 46% G;G 35%
  • Chinese (Denver)A;A 36% A;G 45% G;G 19%
  • Gujarati IndianA;A 15% A;G 33% G;G 53%
  • Luhya (Kenya)A;A 10% A;G 45% G;G 46%
  • Mexican ancestry (Los Angeles)A;A 31% A;G 53% G;G 16%
  • Maasai (Kenya)A;A 5% A;G 36% G;G 59%
  • TuscanA;A 5% A;G 42% G;G 53%

Other MAP2K5 SNPs

All MAP2K5 SNPs

Source and license

Adapted from rs2241423 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.