rs45487699

A SNP in the LDB3 gene on chromosome 10. Its most notable genotype is C;T: left ventricular noncompaction (reported)

Gene
LDB3
Location
Chr 1086,681,680 (GRCh38)
Highest magnitude
4.0Very important
Tested on
23andMe, AncestryDNA
Minor allele frequency
<1%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon in clinvarTypical · 0.0
  2. C;TMost notableBadleft ventricular noncompaction (reported)Very important · 4.0

On SNPedia: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other LDB3 SNPs

All LDB3 SNPs

Notes

From SNPedia

Notes

rs45487699, also known as c.566C>T, p.Ser189Leu and S189L, is a rare mutation in the LDB3 gene on chromosome 10. Inherited as an autosomal dominant, it reportedly leads to a form of left ventricular noncompaction. See OMIM 605906.0005

C;T

see discussion at rs45487699

Source and license

Adapted from rs45487699 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.