rs4765623

A SNP in the SCARB1 gene on chromosome 12. Its most notable genotype is C;C: more likely to gain weight if taking olanzapine

Gene
SCARB1
Location
Chr 12124,836,304 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
39%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadmore likely to gain weight if taking olanzapineTypical · 0.035% of people
  2. C;TBadmore likely to gain weight if taking olanzapineTypical · 0.049% of people
  3. T;TNot ratednormalTypical · 0.016% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 35% C;T 49% T;T 16%
  • European ancestry (Utah)C;C 43% C;T 44% T;T 13%
  • Han Chinese (Beijing)C;C 35% C;T 52% T;T 13%
  • Japanese (Tokyo)C;C 27% C;T 51% T;T 22%
  • Yoruba (Nigeria)C;C 35% C;T 47% T;T 19%
  • African ancestry (Southwest US)C;C 30% C;T 58% T;T 12%
  • Chinese (Denver)C;C 31% C;T 51% T;T 17%
  • Gujarati IndianC;C 47% C;T 42% T;T 12%
  • Luhya (Kenya)C;C 41% C;T 49% T;T 10%
  • Mexican ancestry (Los Angeles)C;C 19% C;T 53% T;T 28%
  • Maasai (Kenya)C;C 30% C;T 53% T;T 17%
  • TuscanC;C 46% C;T 43% T;T 11%

Conditions, medicines and genes

Other SCARB1 SNPs

All SCARB1 SNPs

Notes

From SNPedia

Notes

rs4765623 is a SNP in the scavenger receptor class B, member 1 SCARB1 gene. In a study of 67 mostly Caucasian patients prescribed the atypical antipsychotic olanzapine, carriers of a rs4765623(C) allele were more likely to gain significant weight compared to rs4765623(T;T) carriers, as assessed by physiogenomic analysis of corresponding weight profiles. Two other SNPs, rs5092 and rs7412, were also significantly associated with weight profiles in these patients. Combining fMRI and SNP data to investigate connections between brain function and genetics using parallel ICA.

Source and license

Adapted from rs4765623 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.