rs5888

A SNP in the SCARB1 gene on chromosome 12. Its most notable genotype is A;G: 3x higher risk for age-related macular degeneration

Gene
SCARB1
Location
Chr 12124,800,202 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
33%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GGoodhigher HDL cholesterol but lower risk for age-related macular degenerationMinor · 1.553% of people
  2. A;GMost notableBad3x higher risk for age-related macular degenerationWorth knowing · 2.538% of people
  3. A;ANot ratedlower HDL cholesterol but higher risk for age-related macular degenerationWorth knowing · 2.09% of people

SNPedia records rs5888 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 53% A;G 38% A;A 9%
  • European ancestry (Utah)G;G 19% A;G 54% A;A 28%
  • Han Chinese (Beijing)G;G 58% A;G 37% A;A 5%
  • Japanese (Tokyo)G;G 63% A;G 33% A;A 4%
  • Yoruba (Nigeria)G;G 81% A;G 19% A;A 0%
  • African ancestry (Southwest US)G;G 71% A;G 27% A;A 2%
  • Chinese (Denver)G;G 55% A;G 40% A;A 6%
  • Gujarati IndianG;G 35% A;G 52% A;A 14%
  • Luhya (Kenya)G;G 50% A;G 44% A;A 7%
  • Mexican ancestry (Los Angeles)G;G 43% A;G 43% A;A 14%
  • Maasai (Kenya)G;G 72% A;G 26% A;A 3%
  • TuscanG;G 35% A;G 42% A;A 23%

Other SCARB1 SNPs

All SCARB1 SNPs

Notes

From SNPedia

Notes

rs5888 is a SNP in the scavenger receptor class B, member 1 SCARB1 gene. In a case-control study of two Caucasian populations totaling 2,498 patients, rs5888(C;T) heterozygotes had an increased odds ratio of 2.9 (CI: 1.6-5.3, p 0.0015) for rs5888(C;T) heterozygotes.

Source and license

Adapted from rs5888 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.