rs74830677
A SNP in the SCARB1 gene on chromosome 12. Its most notable genotype is A;A: reported to be associated with higher HDL-C
- Gene
- SCARB1
- Location
- Chr 12124,800,125 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- Not on consumer chips
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;GGoodcommon/normal
- A;GBadreported to increase heart disease risk yet also HDL-C (by 8.4mg/dl)
- A;AMost notableBadreported to be associated with higher HDL-C
SNPedia records rs74830677 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Notes
From SNPedia
Show notes, about 130 words
rs74830677, also known as c.1127C>T, p.Pro367Leu and P367L, represents a rare variation in the SCARB1 gene on chromosome 12. Targeted exome sequencing lipid-modifying genes in 328 individuals with extremely high plasma HDL-C levels led to the discovery of a rs74830677(T;T) homozygote. In a total of 852 individuals with high HDL-C compared to 1,156 with low HDL-C, the rs74830677(T) allele was significantly over-represented and, surprisingly, it was also associated with increased risk for coronary heart disease (odds ratio 1.79, p<0.0001). A carrier of the (T) allele appears to have a higher HDL-C of 8.4mg/dl on average. The variant allele was also said to apparently be relatively specific to Ashkenazi Jews.
A;G
see discussion at rs74830677
A;A
see discussion at rs74830677
Source and license
Adapted from rs74830677 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.