rs5558
A SNP in the SLC6A2 gene on chromosome 16. Its most notable genotype is A;A.
- Gene
- SLC6A2
- Location
- Chr 1655,699,647 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableNot ratedNo summary available.
- G;GNot ratedNo summary available.
- G;TNot ratedNo summary available.
- T;TGoodnormal
On SNPedia: (A;A), (G;G), (T;G), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 9 HapMap populations.
- AverageA;A 0% G;G 0% G;T 1% T;T 99%
- European ancestry (Utah)A;A 0% G;G 0% G;T 0% T;T 100%
- Han Chinese (Beijing)A;A 0% G;G 0% G;T 2% T;T 99%
- Japanese (Tokyo)A;A 0% G;G 0% G;T 0% T;T 100%
- Yoruba (Nigeria)A;A 0% G;G 0% G;T 0% T;T 100%
- African ancestry (Southwest US)A;A 0% G;G 0% G;T 4% T;T 97%
- Gujarati IndianA;A 0% G;G 0% G;T 1% T;T 99%
- Luhya (Kenya)A;A 0% G;G 0% G;T <1% T;T 99%
- Mexican ancestry (Los Angeles)A;A 0% G;G 0% G;T 2% T;T 98%
- TuscanA;A 0% G;G 0% G;T 1% T;T 99%
Related
Conditions, medicines and genes
Other SLC6A2 SNPs
- rs3785143C;Tmay be associated with ADHDMinor
- rs5568A;Acommon in clinvarTypical
- rs5569G;Gcommon in clinvarTypical
- rs187715T;TNo summary available.Typical
- rs734980A;Acommon in complete genomicsTypical
- rs998424G;Gcommon in clinvarTypical
- rs2242446C;Ccommon in clinvarTypical
- rs3785152C;Ccommon in complete genomicsTypical
Notes
From SNPedia
Notes
rs5558 (F528C) is a non-synonymous SNP in SLC6A2 (norepinephrine transporter), with a T encoding for Phenylalanine and C encoding the rare Cysteine variant. assoc. w/ major depression Cysteine variant exhibited increased norepinephrine transport, insensitivity to protein kinase C induced down-regulation, and a decrease in desipramine (tricyclic antidepressant) potency
Source and license
Adapted from rs5558 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.