rs587777612
A SNP in the SH2D1A gene on chromosome X. Its most notable genotype is C;C: Lymphoproliferative syndrome 1 (predicted)
- Gene
- SH2D1A
- Location
- Chr X124,346,784 (GRCh38)
- Highest magnitude
- 8.8Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CMost notableBadLymphoproliferative syndrome 1 (predicted)
- C;GBadCarrier of an X-linked mutation for lymphoproliferative syndrome 1
- G;GGoodcommon in clinvar
On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other SH2D1A SNPs
- rs111033623T;TLymphoproliferative syndrome 1 (predicted)Very important
- rs111033624C;CLymphoproliferative syndrome 1 (predicted)Very important
- rs111033625A;ALymphoproliferative syndrome 1 (predicted)Very important
- rs111033626T;TLymphoproliferative syndrome 1 (predicted)Very important
- rs111033627T;TLymphoproliferative syndrome 1 (predicted)Very important
- rs111033628T;TLymphoproliferative syndrome 1 (predicted)Very important
- rs111033629T;TLymphoproliferative syndrome 1 (predicted)Very important
- rs111033630T;TLymphoproliferative syndrome 1 (predicted)Very important
Notes
From SNPedia
Notes
aka c.137+5G>C considered pathogenic for X-linked Lymphoproliferative syndrome, type 1 in ClinVar
C;C
X-linked condition; see links via main rs-page
C;G
see links via main rs-page
Source and license
Adapted from rs587777612 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.